This educational-methodical recommendation is designed for teachers and students of VI-year medical institutions. It focuses on the clinical and pharmacological approaches to rational prescribing of anti-inflammatory drugs and immunomodulators. The purpose is to help students choose the appropriate range of drugs for a specific disease based on etiology, pathogenesis, mechanism of action, route of administration, dosage regimen, patient characteristics, and pharmacokinetic characteristics. The recommendation also includes planning the duration of therapy, criteria for assessing efficacy and safety of the treatment.