This document provides guidelines for healthcare workers dealing with patients infected with Category A agents such as cholera and plague. It emphasizes the importance of placing patients in separate rooms or cohorted together, regular decontamination of rooms, surfaces, and equipment with sodium hypochlorite, and the use of fit tested N95 respirators, protective suits, and goggles. Airborne transmission precautions are recommended during aerosol generating procedures. It also outlines criteria for patient discharge from isolation.